Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle.
نویسندگان
چکیده
An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2'S-isomer.
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عنوان ژورنال:
- Chemical communications
دوره 51 24 شماره
صفحات -
تاریخ انتشار 2015